ABSTRACT
@EN Polycystic ovary syndrome (PCOS) is the combination of ovulatory failure, infertility, hirsutism, obesity, bilateral polycystic ovaries and large numbers of endocrine dysfunctions. In 12 women with PCOS and 9 control women with regular cycle,
the GH
response to L-dopa and insulin response to oral glucose tolerence test were investigated. In PCOS, L-dopa test with pyridostigmine pretreatment was also performed. GH response and GH response area under the curve (AUC) to L-dopa were
significantly
lower
in PCOS (basal (ng/ml), maximum (ng/ml), GH response AUC (ng/mlxh), 0.5±0.2, 1.6±0.7, 2.1±0.7) than those (1.4±0.2, 6.9±1.1, 9.7±1.0) of controls (p<0.05). Pyridostigmine pretreatment had significantly enbhanced the GH response to L-dopa
(1.4±0.4, 7.7±1.3, 9.6±1.4) in PCOS (p<0.05). Insulin response (uU/ml) and insulin response AUC (uU/mlxh) to glucose load were significantly higher in PCOS (8.0±1.8, 142.1±59.5, 194.3±73.7) than those (5.3±1.2, 24.9±2.6, 35.9±2.8) of
controls
(p<0.05). Plasma IGF-1 levels of PCOS (442.3±48.3ug/L) were significantly higher than controls (287.3±27.1) (p<0.05). BMI had a positive correlation with insulin response AUC (p<0.01). Insulin response AUC had a positive correlation with plasma
IGF-1
levels (p<0.001) but inverse correlation with GH response AUC in PCOS and controls (p<0.05).
These data suggest that decreased GH secretion of PCOS may be associated with a high somatostatin activity and a high plasma IGF-1 level. (J Kor Soc Endocrinol 8:265~272, 1993)
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